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PMID 18815130

Exposure to ATZ reduces the mRNA expression of steroidogenic genes ( StAR , CYP17A1 , and 17-HSD ) which is directly linked to decreased androgenesis, thus, impairs the steroidogenesis of Leydig cells 108

MGMT is potentially important for guiding the use of the chemotherapeutic agent temozolomide (TMZ) in GBM, and MGMT promoter methylation is significantly associated with improved overall survival in GBM patients (Sareen et al., 2022)