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Impaired lymphatic fluid flow results in the accumulation of inflammatory cells and neurotoxic elements, impairing the clearance of toxic molecules and metabolites from the ventricles and deep gray matter, as well as the clearance of inflammatory microglia, thereby exacerbating cortical demyelination and gray matter pathology (9496)

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This represents an epigenetic regulatory pathway distinct from the peptides telomerase and melatonin activities