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DS develops various complications such as neurological, skeletal, cardiovascular, and immunological defects 1 , but is perhaps best known for being the most common genetic cause of mental retardation and intellectual disability 2 , occurring at a rate of 1 in 800 to 1000 births 3,4

Patients with borderline deficiency or high stress loads tend to notice more pronounced changes early on

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Dose discipline: Adhere strictly to conservative dosing

Bottom line When taking semaglutide, adhering to the recommended dosage chart is critical to prevent the potential side effects associated with a rapid dose escalation

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