There have been investigations of drugs (e.g., Silymarin) in which its mechanism of action is the activation of NRF-2 either directly or indirectly, and the decrease of the levels of OS components, specifically in liver diseases such as fatty liver [98,99]
Integrins and the activation of latent transforming growth factor 1 - an intimate relationship
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It is a peptide specifically a pentadecapeptide of 15 amino acids
There is also a rising interest in dual GLP-1R/GIPR agonists as neuroprotective drugs that act on respective homoreceptors located in the central nervous system (CNS), with proof that these peptides could also pass through the BBB (6264)