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Lipid nanoparticles (LNPs) have the ability to encompass both hydrophilic and lipophilic compounds, emerging as encouraging drug delivery systems for improved active targeting and penetration into the BBB (164)

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Or otherwise, using the intracranial implants, or temporary disruption of the BBB using osmotic agents or ultrasound [2,8,9,10,11]

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Alba AC, Kirklin JK, Cantor RS, Deng L, Ross HJ, Jacobs JP, et al

4.4 Practical considerations in pharmacokinetics and administration routes The synovial cavity, as a natural enclosed space, provides an ideal window for local drug delivery, allowing drugs to act on the lesion site at high concentrations while minimizing systemic exposure and associated potential risks (Yu et al., 2024