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Contraindications and Safety Considerations That Affect Switching Decisions Before initiating tirzepatide or any incretin agent, screen for a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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These effects were mapped to the central nervous system, lungs, cardiovascular system, liver, kidneys, intestines, and joints in a 2025 review published in the Journal of Clinical Investigation

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Can this be combined with other treatments

Each compound has its own evidence base