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Such impairments closely parallel the mitochondrial respiratory deficits and elevated oxidative markers reported in cortical and limbic regions of depressed individuals, which would impair energy-dependent neuroplastic processes, intracellular signal transduction cascades, and activity-dependent protein synthesis required for synaptic maintenance, dendritic remodelling, and adaptive circuit function [138, 143]

Cortisol, a glucocorticoid hormone, is known to have neurotoxic effects when present in excess

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Likewise, they've never been tested since, so it is possible that I have mild hypothyroidism that the Carbamazepine just aggravated and that really I might have an issue there (there is a family history of it)

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