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Reducing dietary loads of red meat and high-choline foods while increasing plant-based fiber intake simultaneously reduces substrate availability and feeds the beneficial Bifidobacterium and Lactobacillus populations that compete with TMA-producing bacteria

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In a phase II study of the long-acting GLP-1RA efpeglenatide (4 mg once weekly, 6 mg once weekly, 6 mg once every 2 weeks, and 8 mg once every 2 weeks), patients with obesity and without diabetes had statistically significant reductions in body weight compared with placebo after 20 weeks of treatment (differences in least squares means were 6.3 to 7.2 kg

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