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Although in this study and in our previous study [23] on HepG2 cells, we have used ASA to elucidate COX-independent mechanisms of drug action, there are reports that suggest that salicylate, an active metabolite of aspirin, has more or less similar mechanisms of action on mitochondrial-induced apoptosis [30], [31]

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Actually, in the 1950s, many people with a diagnosis of pernicious anaemia were treated with high doses of folate, as B12 injections were not yet available

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Compound Reference Data Compound: PT-141 CAS Number: 189691-06-3 Molecular Formula: C50H68N14O10 Molecular Weight: 1025.18 g/mol Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH Synonyms: Bremelanotide, Vyleesi, PT 141 Selected Published Studies The following peer-reviewed studies were conducted using animal models or in vitro cell-culture systems