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More than half had type 2 diabetes and around 75% were obese
However, causal relationships have yet to be established, and further investigation is needed to confirm their therapeutic potential
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For instance, the disproportionately high prevalence of MASLD among Hispanic populations corresponds to a higher frequency of the PNPLA3 I148M variant, which promotes triglyceride retention in hepatocytes and aggravates insulin resistance ( 2.4 Pathophysiology linking MASLD to T2DM development The link between MASLD and T2DM extends beyond mere coexistence, as both conditions share common pathophysiological mechanisms, primarily insulin resistance and compensatory hyperinsulinemia, which lead to metabolic dysfunction and -cell failure ( Figure 1 )
If you are walking up to the pharmacy counter without any insurance coverage, you might experience severe sticker shock
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