The original rationale for combining GLP-1 and GIP, the other predominant incretin hormone, was to leverage the individual islet effects of each hormone to impart superior glycemic control
We synthesize current mechanistic and clinical observations within a framework of energy flux constriction and substrate proportionality, highlighting metabolic factors that may influence nutritional stability during sustained pharmacological weight reduction
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doi: 10.1210/clinem/dgaa863 Summary Keywords obesity, insulin-resistance, Tirzepatide, pathophysiology, GIP, GLP - 1, clinical trials, arterial hypertension Citation Corrao S, Pollicino C, Maggio D, Torres A and Argano C (2024) Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence