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In May 2025, Novos CEO Lars Jrgensen stated that the copycat market is as large as our own obesity business. Analysts estimate up to 30% of U.S

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and COL1A1 downregulation (UVB activates collagen-suppressing pathways via ERK1/2-AP-1 at the AP-1 site of the COL1A1 promoter)

Several alternative therapeutic strategies have been investigated, including protein kinase C inhibitors [10], darbepoetin alfa [11], endothelin receptor antagonists (ERAs) [12], direct renin inhibitors [13], nuclear factor erythroid 2-related factor 2 activators [14], and combination of ACE inhibitor and ARB [15]

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