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Abbreviations EVs: Extracellular vesicles EXOs: Exosomes MVs: Microvesicles ABs: Apoptosis bodies ILVs: Intraluminal vesicles MVEs: Multivesicular endosomes Ti-EVs: Tissue-derived EVs AD: Alzheimer's disease ECM: Extracellular matrix FBS: Fetal bovine serum MVBs: Multivesicular bodies SEC: Size exclusion chromatography NTA: Nanoparticle tracking analysis WB: Western blot PBS: Phosphate buffered saline PMI: Post-mortem interval TEM: Transmission electron microscope sEVs: Small EVs lEVs: Large EVs UC: Ultracentrifugation UF: Ultrafiltration GO: Gene ontology RCC: Renal cell carcinoma ccRCC: Clear cell renal cell carcinoma DAMP: Damage-associated molecular pattern IFN: Interferon gamma AA: Arachidonic acid EVP: Extracellular vesicles and particles EMT: Epithelialmesenchymal transition BCa: Bladder cancer NSCLC: Non-small cell lung cancer OCC: Ovarian clear cell carcinoma AEH: Atypical endometrial hyperplasia ERK: Extracellular signal-regulated kinases ADSCs: Adipose-derived stem cells ATMs: Adipose tissue macrophages BMIs: Body mass index BCC: Breast cancer cell LECs: Lymphatic endothelial cells PVAT: Perivascular adipose tissue VSMC: Vascular smooth muscle cells WAT: White adipose tissue IR: Insulin resistance FAO: Fatty acid oxidation FA: Fatty acids HFD: High-fat diet References Allen M, Bjerke M, Edlund H, Nelander S, Westermark B (2016) Origin of the U87MG glioma cell line: good news and bad news

In all, GLP-1 receptor agonists were correlated with reduced risks for 10 of the 13 OACs investigated in the study

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Obesity is defined as: A body mass indexBMIof 30 kg/m2 or greater) Overweight is defined as: A BMI of 27 kg/m2 or greater These drugs are expensive

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