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A high glucose level did not increase the cAMP levels stimulated by 100-M DCA or 10-mM L-glutamine, suggesting that high glucose potentiates Gs activation-stimulated GLP-1, but not via cAMP in GLUTag cells (Fig

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All GLP-1 agonists, SGLT2 inhibitors and their availability are described in Supplement 1

10.1371/journal.pone.0283806 58 LiJ.RenC.WangL.-X.YaoR

doi: 10.1038/s12276-023-01114-w

Retatrutide (LY-3437943) is a synthetic 39-amino-acid peptide developed as a triple agonist of the GLP-1, GIP and glucagon receptors