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Zhang J, Li H, Huo R, et al

When to Consider Changing Approaches If a therapy has been implemented consistently and with high fidelity for a reasonable period typically three to six months without evidence of meaningful progress, it is appropriate to reconsider the approach

This approach may result in less dramatic weight loss or glycemic improvement but can significantly improve tolerability and treatment adherence

Another option for estrogen delivery is based on a peptide carrier that selectively delivers estrogens to specific tissues

Fadini et al

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