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Cultured human keratinocytes have been suggested as good models to predict dermal irritancy of substances in human subjects 31

The weight loss mechanism differs as well: GLP-1 agonists work through delayed gastric emptying and central appetite suppression, while berberine's weight effects, when present, likely relate to improved insulin sensitivity and metabolic efficiency

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Front Neuroendocrinol (2016) 42:7692

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