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This finding is in agreement with other studies that proved that reduction of antioxidants including uric acid in smokers66 is due to both chronic exposure to cigarette smoke that is a significant source of oxidative stress8,53 and low intake of dietary antioxidants.67 CONCLUSION After exclusion of other factors affecting uric acid level, the significant low serum uric acid level in smokers was attributed to reduce endogenous production as a result of chronic exposure to cigarette smoke that is a significant source of oxidative stress