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By eliminating dysfunctional mitochondria, autophagy, and more specifically mitophagy, is thought to help limit excessive ROS formation, release of DAMPs, and amplification of inflammatory responses in AP ( Selective autophagy of mitochondria (mitophagy) is triggered when damaged or depolarized mitochondria accumulate PINK1 on the outer mitochondrial membrane, leading to recruitment and activation of the E3 ubiquitin ligase Parkin