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Melatonin is synthesized from the amino acid L-tryptophan through a series of enzymatic reactions

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Therefore, LDR-induced stresses convergently led to the permanent changes in the cells

As it interacts with NO to form S-nitrosoglutathione (GSNO), it stabilizes NO so it is released slowly

In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)