The researchers assessed the hepatic capacity for synthesizing urea-N (CUNS), which is a potential indicator of nitrogen metabolism in the liver
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In the MAESTRO-NASH trial, patients across all groups received nutritional and exercise counseling in accordance with the 2018/2023 AASLD Practice Guidance recommendations, which advocated for weight loss through a hypocaloric diet and nutritional modification (daily reduction of 500 to 1000 kilocalories), either alone or in combination with moderate-intensity exercise 42,43
10.1038/nrneurol.2017.147 301 WangC.ReidG.MackayC
Administration should occur via subcutaneous injection, with recommended injection sites including the abdomen, thigh, or upper arm