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Have acute or chronic metabolic acidosis (including diabetic ketoacidosis)

Ann Occup Hyg 54: 944-954, 2010

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In addition, p -cresol is also likely to deplete GSH as, like APAP, it is a substrate for oxidative metabolism, forming reactive metabolites (RMs) via CYP P450-mediated metabolism (both a quinone methide via CYP2D6, 2C19, 1A2, 1A1, and 2E1 and a 4-methyl- o -hydroquinone that is further oxidized to 4-methyl-1,2-benzoquinone, mainly via CYP2E1 but also CYP1A1, 1A2, and 2D6)36 potentially reducing the ability of the host to simultaneously detoxify APAP-derived RMs

So when it comes to objects just dozens of meters wide that are out around Jupiters orbit, which is always at least 350 million miles (560 million km) from Earth, scientists are simply out of luck to spot them directly