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60 When gallstones obstruct the cystic duct, bile flow is impeded, resulting in bile stasis and increased pressure within the gallbladder

Insulin resistance is the most potent pathogenic potentiator, which promotes a pro-inflammatory state, with increased lipolysis, de-novo lipogenesis and free-fatty acid flux

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A 2019 study in Diabetes, Obesity and Metabolism found that lixisenatide significantly increased urinary excretion of sodium and other electrolytes during prolonged therapy

Increasing the Dose Gradually Most doctors increase the dose gradually

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