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The biggest limitation is that the study cannot prove cause and effect, Sudhakaran says

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Epidemiologic studies have demonstrated that at least 6% of filled prescriptions for either acetaminophen alone or acetaminophen in combination with opioids exceeded 4000 mg per day of acetaminophen, which is a cause for real concern.3,5,6 Further epidemiologic studies have demonstrated that there is a true lack of knowledge regarding the harmful potential of APAP

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