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Depending on the population, 20% to 53% of individuals may have inherited one T copy (677C/T genotype), and 3% to 32% of individuals may have inherited two T copies (677T/T genotype) for the MTHFR gene (22)

The inflammatory mechanism plays a role in the development of epilepsy associated with T2DM, as inflammatory biomarkers such as interleukins (IL-1, IL-6, and IL-8), tumor necrosis factor-, high-mobility group box 1, and toll-like receptors are elevated in both epileptic seizures and T2DM (91)

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Melatonin levels were determined taking all the necessary care to prevent light degradation by using the melatonin enzyme immunoassay kit (IBL Hamburg, Germany)

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