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Additionally, mast cells directly respond to gliadin fragments (part of the gluten protein) and release proinflammatory mediators.[ref] Related article: Celiac Genes Ehlers-Danlos, Hypermobility, and Mast Cell Activation: As mentioned above, mature mast cells are found in tissues and congregate in the connective tissue around lymphatic vessels, blood vessels, nerves, and skin

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Researchers there identified it as unusually stable in stomach acid, which is rare for peptides

This multi-faceted mechanism of action makes it a subject of intense study in metabolic research