explored the therapeutic potential of silencing HIF-1 using RNAi in U251, U87, and U373 glioma cells
However, the rapidly expanding body of research surrounding cellular bioenergetics and the redox cycle offers a beacon of realistic hope
For example, ascorbate was found to have a specific and light-dependent effect on the expression of the gene encoding the chloroplast 2-Cys peroxiredoxin-A2, an effect that could not be substituted by GSH (Shaikhali and Baier, 2016)
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Related research revealed that hypoxia causes endoplasmic reticulum stress in oligodendrocytes and endothelial cells [26, 27]
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