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These side effects are generally dose-manageable and often resolve with dose adjustment or time

Some tolerate the drugs, but others experience nausea and vomiting so unpleasant that they stop taking them

Its levels drop during the day, with some peaks depending on the number of stress-causing situations

"For all their promise, GLP-1 agonists have raised more questions than they have answered a hallmark of a true breakthrough," wrote Holden Thorp, Science journals' editor-in-chief, in an Editorial in the latest issue of Science

These changes were similar to those observed in the hyperlipidemia progression period