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Proc Natl Acad Sci USA 98:1046310468 Patel RP, McAndrew J, Sellak H, White CR, Jo H, Freeman BA, Darley-Usmar VM (1999) Biological aspects of reactive nitrogen species

The principle lipase implicated in TBI is cytoplasmic phospholipase A2 (cPLA2), which is upregulated after in vivo and in vitro experimental TBI and preferentially cleaves arachidonic acid as an essential part of enzymatic lipid peroxidation and inflammatory signal transduction [82]

Nissen A, Yi F

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Until about the early 1990s, it was kind of laughable that you could develop a pill that would slow aging, said Richard Miller, a biogerontologist at the University of Michigan who heads one of three labs funded by the National Institutes of Health to test such promising substances on mice