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Molecular size is important, but shape is also critical, since individual molecules need to fit together cooperatively for the attractive lattice forces to be large

Some protocols use an extended break matching the cycle length (8 weeks on, 8 weeks off)

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Epub 2001/12/18

Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration

Endocrinology 145 , 667678 (2004)