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Description

FGF-21 enhances mitochondrial deacetylase SIRT3 expression via AMPK-mediated FOXO3 phosphorylation, safeguarding against lipotoxicity-induced mitochondrial dysfunction and oxidative stress [246]

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And that conversation should be evidence-ranked and safety-firstnot trend-first

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It is well documented that patients with neurofibromatosis type 1 (NF1) have a greater lifetime risk of developing MPNSTs (813%) and worse prognosis in comparison with sporadic cases, with 5-year disease-specific survival of 1638% versus 4257%, respectively [2, 5,6,7,8,9,10]

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10.1038/aps.2011.149

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10.1007/s00299-010-0985-7 118 SatoY.MurakamiT.FunatsukiH.MatsubaS.SaruyamaH.TanidaM

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