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Studies investigated mechanisms of target-site resistance ( n = 2), or metabolic resistance ( n = 10), and/or changes to multi-resistant protein (MRP) transporter expression ( n = 12)

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Overall, it is clear that NAD + fluxes within the cell are complex and dynamic, but the concentrated levels of NAD + in the mitochondria indicate major impacts of the cofactor in this organelle in particular, which will be summarized below

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The route must be documented in the medical record before the claim goes out