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Methods Ethics declarations All the animal experiments were performed following the Guide for Care and Use of Laboratory Animals, approved by the Animal Experimentation Ethics Committee of China Pharmaceutical University (2022-10-017)

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Clinical trials demonstrate that tirzepatide users experience reduced hunger hormones, improved satiety from smaller meals, and measurable improvements in metabolic markers like fasting glucose and cholesterol levels

The two conditions can coexist but have different anatomical origins, hormonal drivers, and treatment approaches

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