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The idea that oral, non-smoked, tobacco causes head and neck cancer can be traced directly to an NEJM article published 44 years ago.1[i] That study, authored by Deborah Winn and colleagues, appeared the same year that I began my 24-year faculty career at the University of Alabama at Birmingham School of Medicine as an oral and maxillofacial pathologist

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This remarkable cell diversity derives from the basal airway stem cell by way of multiple branching lineages 1,2 , yet, the nature of these lineages, their transcriptional regulation, and the functional heterogeneity to which they lead, remain incompletely defined in humans

The Correct Answer Yes, cigarette packages are paperboard