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doi:10.1016/j.immuni.2015.10.012

2 In the following decades, Christian de Duves discovery of lysosomes and his subsequent identification of autophagy defined intracellular degradation and recycling pathways as central elements of proteostasis

The study also revealed an unexpected pathway-dependent response: in telomerase-positive cancer cell lines, telomere elongation occurred through alternative lengthening of telomeres (ALT) activation rather than telomerase upregulation, suggesting that the AEDG sequences interaction with telomere maintenance pathways is more complex than initially characterized