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Because SGLT2 is involved in sympathetic nervous system activation, inhibiting it can lower renal afferent nervous activity and suppress central reflex mechanisms that lead to widespread sympathetic activation [61]

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Clinical Significance and Future Directions The differences in HbA1c and weight reduction suggest that tirzepatides dual agonism may offer improved glycemic control and weight loss benefits for patients with T2D compared to a single agonist like semaglutide, potentially reducing diabetes-related complications

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