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Researchers have yet to establish a clear causal link between GLP-1 medications and these vision complications

As gastric emptying slows, patients may develop sensations of nausea or fullness

Therefore, whether the p21GPX4 axis is a universally present protective mechanism in OA still awaits broader data support (Figure 1)

Saturation in this transport mechanism could lead to leptin resistance

For instance, PT-141 may reduce neuroinflammation by inhibiting the NF-B signaling pathway, thereby shielding neurons from damage caused by oxidative stress and inflammatory reactions

However, some patients may inadvertently consume insufficient calories, protein, or essential nutrients, leading to muscle fatigue, weakness, and soreness